CLEO 2013: Lab-on-a-chip meets optics

Thanks to Chris Myatt for a heads up on some interesting sessions he is organizing at the Conference on Lasers and Electro-Optics (CLEO) Conference in San Jose, June 9-14. Some fantastic talks, including one from Valerie Ng who’ll be talking about end user perspectives — what do they really want to see? Definitely worth checking out!

Monday, June 10, 13:30 — 15:30

AM3M • Symposium on Lab-on-a-Chip Applications: Lab on Chip I

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon III (Marriott San Jose)

AM3M.1 • 13:30 Invited Submission

Computational On-Chip Imaging Toward Telemedicine Applications, Aydogan Ozcan1; 1Electrical and Bioengineering Departments, University of California Los Angeles, USA. We review our recent work on computational on-chip imaging and its applications to telemedicine and high-throughput microscopy, including wide-field imaging of individual viruses on a chip

AM3M.2 • 14:00 Invited Submission

Smartphone Based Optical Detection of Kaposi’s Sarcoma Associated Herpesvirus DNA, Matthew Mancuso1, David Erickson2; 1Department of Biomedical Engineering, Cornell University, USA; 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, USA. We create a smartphone accessory that is capable of optically reading out a detection reaction in a microfluidic chip and test it using a colorimetric reaction targeted at DNA from Kaposi’s sarcoma associated herpesvirus.

AM3M.3 • 14:30 Invited Submission

SMART (Shrink Manufacturing Advanced Research Tools), Michelle Khine1;1University of California, Irvine, USA. Leveraging the inherent heat-induced relaxation of pre-stressed thermoplastic sheets, we pattern in a variety of ways at the large scale and achieve micro and nanostructures by controlled shrinking down to 5% of the original patterns.

AM3M.4 • 15:00 Invited Submission

Microfluidics Facilitated Genome Sequencing for Limited Number of Cells, Liang Zhao1, Xiannian Zhang1, Aaron M. Streets1, Yuhong Pang1, Fuchou Tang1, Yanyi Huang1; 1Biodynamic Optical Imaging Center (BIOPIC), Peking University, China. We develop a microfluidics-based single cell RNA-Seq transcriptome analysis technology to perform the library-prep reaction steps at nanoliter range within sealed chambers on-chip, eliminating potential contaminations and sophisticated manual handlings.

Monday, 10 June, 16:00 — 18:00

AM4M • Symposium on Lab-on-a-Chip Applications: Lab on Chip II

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon III (Marriott San Jose)

AM4M.1 • 16:00 Invited Submission

From Lab-on-a-Chip to Lab-in-the Body: Miniaturization of Diagnostic Tools, Axel Scherer1; 1California Institute of Technology, USA. Optical molecular diagnostic tools are rapidly shrinking, enabling miniature systems that can be used to continuously monitor health in the body. We describe our work on integrated photonic systems for this purpose.

AM4M.2 • 16:30 Invited Submission

Where the Rubber Meets the Road – Clinical Diagnostic Testing and New Technology, Valerie Ng1; 1Alameda County Medical Center/HGH, USA. Diagnostic test devices using new and emerging technologies must meet regulatory standards for clinical use. I will discuss these regulatory requirements emphasizing how test device manufacturers can meet the needs of the clinical laboratory.

AM4M.3 • 17:00 Contributed Submission

Optofluidic Electrical Manipulation of Individual Biomolecules with nm-scale Precision, Mohammad Soltani1,2, Jun Lin1, Summer Saraf1, Robert Forties1, Michal Lipson2, Michelle Wang1; 1Physics, Cornell University, USA; 2Electrical and Computer Engineering, Cornell University, USA. We design and demonstrate electrically controlled optical trapping of individual microparticles and manipulation of biomolecules with nm-scale precision for high throughput applications. This has been realized by integration of photonics, fluidics, and electronics, on-chip.

AM4M.4 • 17:15 Invited Submission

Second Generation Multiplexed Diagnostics with Silicon Photonics, Cary Gunn1;1Genalyte, USA. No abstract available.

AM4M.5 • 17:45 Contributed Submission

High-Q Mid-Infrared Chalcogenide Glass-On-Silicon Resonators for Spectroscopic Chemical Sensing, Hongtao Lin1, Lan Li1, Yi Zou1, Sylvain Danto2, J. David Musgraves2, Kathleen Richardson2, Juejun Hu1; 1Department of Materials Science & Engineering, University of Delaware, USA; 2College of Optics & Photonics, University of Central Florida, USA. We fabricated and characterized high-index-contrast As2Se3micro-disk resonators on silicon with a record loaded Q-factor of 105 at 5.2 μm wavelength. On-chip chemical sensing using cavity-enhanced infrared spectroscopy was demonstrated using the micro-disk device.

Tuesday, 11 June, 11:00 — 13:00

ATu1N • Symposium on Lab-on-a-Chip Applications: Lab on Chip III

Presider: Chris Myatt; Precision Photonics Corporation, United States

Salon IV (Marriott San Jose)

ATu1N.1 • 11:00 Invited Submission

New Microfluidic Technologies for Accelerating and Enhancing Molecular Binding Processes in Cartridge-format Assay Systems, Daniel Laser1; 1Wave80 Biosciences, Inc., USA. No abstract available.

ATu1N.2 • 11:30 Contributed Submission

Hybrid Optofluidic Device for Fluidic Particle Manipulation and Detection, Joshua Parks1, Jungkyu Kim2,3, Lynnell U. Zempoaltecatl4, Damla Ozcelik1, Hong Cai1, Rich Mathies2, Aaron Hawkins4, Holger Schmidt1; 1School of Engineering, University of California Santa Cruz, USA; 2Chemistry, University of California Berkeley, USA;3Mechanical Engineering, Texas Tech University, USA; 4Electrical and Computer Engineering, Brigham Young University, USA. Integrated fluidic control and optical detection are presented through the synthesis of microfluidic automata and optofluidic waveguides. Analyte mixing and fluid velocity are controlled on Automaton while optical detection is achieved via liquid-core ARROW waveguides.

ATu1N.3 • 11:45 Invited Submission

Lab on a Chip Fluorescence Measurements – from Single Biomolecules to Testing Standards, Samuel Stavis1; 1NIST CNST, USA. Faint fluorescent signals from within lab on a chip devices may be overwhelmed by autofluorescent background noise from nearby surfaces and bulk materials. This measurement challenge becomes increasingly relevant as plastic chips are commercialized and standardized.

ATu1N.4 • 12:15 Contributed Submission

Dynamic switching between microparticle buffering and dropping on a silicon nitride optofluidic microring resonator, Jiawei Wang1, Andrew W. Poon1; 1Photonic Device Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong. We demonstrate dynamic switching between microparticle buffering and dropping on a silicon nitride optofluidic microring resonator by polarization switching. We calculate the cavity-field-enhancement factor as an indicator to explain the transition between buffering and dropping.

ATu1N.5 • 12:30 Invited Submission

Red-emitting Substrates for Rapid Botulinum Neurotoxin Detection, James N. Herron1, Konrad Engelhardt1, Vald O’Mel1; 1University of Utah, USA. We report a new red-emitting molecular beacon for botulinum neurotoxin A suitable for inexpensive rapid assay formats. Reaction kinetics including parameters like Km and Vmax were evaluated in a fluorogenic assay using the BoNT/A light chain.